The Brutal Combo is started by pressing when you are close enough to an enemy. After the first punch has landed, press to continue the combo. After the second blow has landed, press again to finish the combo. Enemies killed with a Brutal Combo will drop more ammo.
- A Brutal Combo can't kill the Descendants.
- Drake uses a Brutal Combo to finish off Atoq Navarro at the end of Chapter 22 - Showdown.
- The Brutal Combo does not appear in Uncharted 2; however, a composition featured in the Uncharted 2 OST is entitled "Brutal Combo Mambo."