Background & early life
Not much is known about Edward's early life. Due to the fact that he lived in an orphanage, there may have been extremities between him and his parents, possibly death, or that they were unwilling to take care of him.
Events of Uncharted 4: A Thief's End
One day at the orphanage, Edward took one of Nathan Drake's books and began teasing him with it, waving it in the air back and forth. Nathan got mad and tackled Edward, leading the two to have a fight before Father Ryan Duffy broke it up. Edward was not punished due to the incident, while Nathan was suspended from going on a retreat with the rest of the orphanage.