New York appears in Uncharted: The Fourth Labyrinth.
Events of The Fourth Labyrinth
The city is the main setting for chapters 2, 3, 4 and 5. Nathan Drake and Victor Sullivan, accompanied by Jada Hzujak, investigate the death of Jada's father. They visit the Museum of Natural History where they meet Gretchen Welch.
Inside the Museum they find Dr. Cheney dead. The police arrive, and the trio are forced to flee.
Once they begin to make their way to Pheonix Innovations, they are attacked by sniper fire. A car chase ensues, ultimately ending in the heroes fleeing by boat.