Their first appearance is in Urban Warfare, when they crash a bus, in what appears to be an attempted ambush and suicide bombing on a group of Zoran Lazarevic's soldiers. This small group are quickly killed by the soldiers. They appear again at the beginning of Desperate Times when another small group of them are summarily executed in the plaza by Lazarevic's men. Their final appearance is in They're Coming With Us, when Nate sees a small group of them being hunted down by a tank.
Although they are a presence in the game, the resistance fighters were never directly encountered by Nathan Drake, and he never interacted with them. They fought for a noble cause, attempting to stop Lazarevic from destroying their city; however, they fought in vain. They were too few in numbers and far too disorganized to stand against Lazarevic, and their attempted uprising was quickly quashed. Lazarevic's men would immediately open fire on any resistance fighters they encounter and mercilessly execute any survivors. Fortunately for them, when Lazarevic's men found out where the passage to Shambhala was hidden, they left the city with all their vehicles and gear to make a raid there.